Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

ERCC8

Gene Name

ERCC excision repair 8, CSA ubiquitin ligase complex subunit

Gene ID

1161

Gene Synonyms

CKN1; CSA; UVSS2

ORF Size

618 bp

RefSeq#

BC009793

Gene Description

ERCC8 encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.

UniGene ID

Hs.435237

HGNC ID

HGNC:3439