Custom AAV Production and AAV Packaging Services
At Vector Biolabs, we work side by side with our clients to design and construct AAV for all research and commercial needs, primarily:
- Custom AAV Production – With a curated gene library in our freezers, productions are typically delivered within 4-5 weeks from design.
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- Custom AAV Production Case: A pharmaceutical company needed AAV vectors encoding 2 neuroprotective factors to inject into brain cells for Parkinson’s disease research. Vector Biolabs helped the customer come up with the best design, cloned both genes into our AAV backbone, and produced the ready for injection AAV virus.
- AAV Packaging Service – With our 20 years of expertise in plasmid packaging, productions are typically delivered within 2-3 weeks from receiving your plasmid.
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- AAV Packaging Case: A research lab aimed to study the role of a novel protein in neuronal development. They provided the plasmid encoding the protein. Vector Biolabs packaged the gene into AAV vectors and ensured precise quality control at each stage. The vectors were then used to transduce neurons, resulting in robust overexpression of the protein.
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AAV Production Process
Frequently Asked Questions
See below for key details on our custom AAV production and packaging services, such as what materials to provide, our production processes, available serotypes and promoters, capacity limits, expression options, yield and titer expectations, quality control processes, and production scales.
Custom AAV FAQ
For over-expression AAV construct, you need to provide us 5-10 ug plasmid DNA, the vector ma, and sequence for your plasmid.
For shRNA AAV service, you should provide the exact RNAi sequence to be cloned into recombinant AAV vector if no plasmid is available. If you already have the shRNA in a plasmid vector, we prefer to use your shRNA plasmid instead of just the shRNA sequence info.
For gRNA AAV, you can provide the gRNA sequence you want to use. Please specify if your gRNA was designed for saCas9 or spCas9.