human ERCC8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ERCC8.
shAAV-210129
AAV-h-ERCC8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CKN1; CSA; UVSS2
Description (Vector)
ERCC8 encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Gene ID
1161
Gene Name (Vector)
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Gene Symbol
ERCC8
HGNC ID
HGNC:3439
ORF Size (aa)
618
ORF Size (bp)
618 bp
RefSeq ID
NM_000082
RefSeq Synonyms
NM_001290285, NM_001007234, NM_001007233, NM_000082, BC009793,
Species
human
UniGene ID
Hs.435237
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.