Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

ESPL1

Gene Name

extra spindle pole bodies like 1, separase

Gene ID

9700

Gene Synonyms

ESP1; SEPA

ORF Size

6360 bp

RefSeq#

BC172238

Gene Description

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 (PubMed 19345191)).(supplied by OMIM, Nov 2010)

UniGene ID

Hs.153479

HGNC ID

HGNC:16856