Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Kdm2a

Gene Name

lysine (K)-specific demethylase 2A

Gene ID

225876

Gene Synonyms

100043628; 5530401A10Rik; AA589516; AW536790; Cxxc8; Fbl11; Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina

ORF Size

2508 bp

RefSeq#

BC076576

Gene Description

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

UniGene ID

Mm.31941