human KDM2A Over-expression AAV

Name 
AAV-h-KDM2A
Cat No 
AAV-212836
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human KDM2A.

AAV-212836
AAV-h-KDM2A

Ready-to-use AAV expressing Human KDM2A (lysine demethylase 2A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Histone-H3-lysine-36 demethylase 1A; CXXC8; CXXC-type zinc finger protein 8; FBL11; FBL7; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; FBXL11; JHDM1A; jmjC domain-containing histone demethylation protein 1A; jumonji C domain-containing histone demethylase 1A; LILINA; lysine (K)-specific demethylase 2A; lysine-specific demethylase 2A
Description (eCommerce)
JHDM1A is a member of the JHDM1 histone demethylase family that contains JmjC domains and regulates transcription. It is also a member of the F-box family of proteins which are components of the SKP1-cullin-F-box (SCF) ubiquitin-protein ligase complex. In addition to the JmjC and F-box domains, JHDM1A also contains a CXXC-type zinc-finger, a PHD-type zinc-finger, and 3 LRR (leucine-rich) repeats.
Description (Vector)
KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
Gene ID
22992
Gene Name (eCommerce)
lysine demethylase 2A
Gene Name (Vector)
lysine demethylase 2A
Gene Symbol
KDM2A
HGNC ID
HGNC:13606
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3489
ORF Size (bp)
3489 bp
Protein Name (eCommerce)
Lysine-specific demethylase 2A
RefSeq ID
NM_012308
RefSeq Synonyms
NM_012308, NM_001256405, BC064360, BC047486, BC047371,
Research Areas
Cancer,Histone Modification,Transcription Factor/Regulator,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
JHDM1A is a member of the JHDM1 histone demethylase family that contains JmjC domains and regulates transcription. It is also a member of the F-box family of proteins which are components of the SKP1-cullin-F-box (SCF) ubiquitin-protein ligase complex. In addition to the JmjC and F-box domains, JHDM1A also contains a CXXC-type zinc-finger, a PHD-type zinc-finger, and 3 LRR (leucine-rich) repeats.
UniGene ID
Hs.124147
UniProt ID (eCommerce)
Q9Y2K7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.