Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein adenovirus
Product Name: Ad-Id-1
Product Category: Pre-packaged Ready-to-use Adenovirus
Catalog No. 1507
Viral Backbone: human Adenovirus Type5 (dE1/E3)
Gene Name: Id-1
Gene Alias: ID, ID1
GeneBank Number: BC000613
Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1, Id2, Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and bHLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Id1 inhibits DNA binding of E12 and Myo D and inhibits muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, which allows E12 and/or E47 to form heterodimers with Myo D and myogenin to activate myogenic differentiation. Expression of each of the Id proteins is strongly dependent on growth factor activation. A reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed re-entry of arrested cells into the cell cycle following growth factor stimulation.
Titer: 1x1010 PFU/ml
Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol
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