B-cell CLL/lymphoma 2

Product Category: human Adenovirus Type5 (dE1/E3)

Gene Name: BCL2

Gene Alias: Bcl2

GeneBank Number: BC027258

Description:

Members of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis). Various homodimers and heterodimers formed by proteins in this family either promote or inhibit apoptosis. Pro-apoptotic members of this family include Bax, Bcl-xS, Bad, Bak, NBK (Bik), BID, Hrk, Bok, Bim, NOXA, Diva and Bmf. Apoptotic inhibitors include Bcl-2, Bcl-xL, Bcl-x(beta), Bcl-x(gamma), Bcl-w, Mcl-1, Bag-1, A1 (Bfl-1), BAR and BI-1 (TEGT). Bok, or Bcl-2 related ovarian killer, induces apoptosis in cells, but is suppressed by anti-apoptotic Bcl-2 family proteins. BECN1 plays a significant role in autophagy. PUMA gene encodes two BH3 domain-containing proteins PUMA(alpha) and PUMA(beta), which have similar binding activities to Bcl-2, localize to the mitochondria to induce cytochrome c release and activate the rapid induction of programmed cell death.

Titer: 1x10¹⁰ PFU/ml

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

References:

• Transcription Factor Gata4 Inhibits Doxorubicin-Induced Autophagy And Cardiomyocyte Death.
  J. Biol. Chem. 2010. 285:793-804.

• PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development
  The Embo Journal. 2010. 29(XX):956-968

Cat. No.	Tag	Promoter		Species	Price **	Availability
1412		CMV		human	$445.00	In Stock

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