Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

USP5

Gene Name

ubiquitin specific peptidase 5

Gene ID

8078

Gene Synonyms

ISOT

ORF Size

2508 bp

RefSeq#

BC004889

Gene Description

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 (PubMed 7578059)).(supplied by OMIM, Mar 2010)

UniGene ID

Hs.631661

HGNC ID

HGNC:12628