human MMACHC Adenovirus
This is an Adenovirus expressing Human MMACHC.
ADV-215551
Ad-h-MMACHC
Ready-to-use Adenovirus expressing Human MMACHC (methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cblC; cyanocobalamin reductase (cyanide-eliminating); methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; methylmalonic aciduria and homocystinuria type C protein
Description (eCommerce)
Methylmalonic aciduria and homocystinuria type C protein (MMACHC) may be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y4U1].
Description (Vector)
The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.
Gene ID
25974
Gene Name (eCommerce)
metabolism of cobalamin associated C
Gene Name (Vector)
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
Gene Symbol
MMACHC
HGNC ID
HGNC:24525
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
678
Protein Name (eCommerce)
Methylmalonic aciduria and homocystinuria type C protein
RefSeq ID
NM_015506
RefSeq Synonyms
NM_015506, NM_001330540, BC006122,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Methylmalonic aciduria and homocystinuria type C protein (MMACHC) may be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y4U1].
UniGene ID
Hs.13024
UniProt ID (eCommerce)
Q9Y4U1
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.