Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

GCHFR

Gene Name

GTP cyclohydrolase I feedback regulator

Gene ID

2644

Gene Synonyms

GFRP; HsT16933; P35

ORF Size

222 bp

RefSeq#

BC143904

Gene Description

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

UniGene ID

Hs.631717

HGNC ID

HGNC:4194