human BACE2 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-201931
Availability:
6-8 weeks
Name:
AAV-h-BACE2-shRNA
This is an AAV expressing shRNA for silencing of Human BACE2.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- BACE2
- Gene Name
- beta-site APP-cleaving enzyme 2
- Gene ID
- 25825
- Gene Synonyms
- AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
- ORF Size
- 1557 bp
- RefSeq#
- NM_012105
- Gene Description
- Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
- UniGene ID
- Hs.529408
- HGNC ID
- HGNC:934
Related Products
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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