mouse GRIA4 shRNA silencing AAV

Cat. No: shAAV-260754

Availability: 6-8 weeks

Name: AAV-m-GRIA4-shRNA

This is an AAV expressing shRNA for silencing of Mouse Gria4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Gria4
Gene Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Gene ID: 14802
Gene Synonyms: GluA4; Glur-4; GluR-D; Glur4; Gluralpha4; spkw1
ORF Size: 2709 bp
RefSeq#: NM_019691
Gene Description: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
UniGene ID: Mm.477102