human GRIA4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GRIA4.
shAAV-210508
AAV-h-GRIA4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GluA4; GLUR4; GLUR4C; GLURD
Description (Vector)
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
Gene ID
2893
Gene Name (Vector)
glutamate ionotropic receptor AMPA type subunit 4
Gene Symbol
GRIA4
HGNC ID
HGNC:4574
ORF Size (aa)
2709
ORF Size (bp)
2709 bp
RefSeq ID
NM_000829
RefSeq Synonyms
NM_001112812, NM_001077244, NM_001077243, NM_000829, BC167786,
Species
human
UniGene ID
Hs.503743
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.