human SCYL1 shRNA silencing AAV

Name 
AAV-h-SCYL1-shRNA
Cat No 
shAAV-222406
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SCYL1.

shAAV-222406
AAV-h-SCYL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SCYL1 (SCY1 like pseudokinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
coated vesicle-associated kinase of 90 kDa; GKLP; HT019; likely ortholog of mouse N-terminal kinase-like protein; NKTL; N-terminal kinase-like protein; NTKL; P105; SCAR21; SCY1-like protein 1; SCY1-like, kinase-like 1; TAPK; TEIF; telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; telomerase transcriptional elements-interacting factor; teratoma-associated tyrosine kinase; TRAP
Description (eCommerce)
TEIF (telomerase transcriptional element-interacting factor) belongs to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes [taken from NCBI Entrez Gene (GeneID: 57410)].
Description (Vector)
SCYL1 encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
57410
Gene Name (eCommerce)
SCY1 like pseudokinase 1
Gene Name (Vector)
SCY1 like pseudokinase 1
Gene Symbol
SCYL1
HGNC ID
HGNC:14372
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2427
ORF Size (bp)
2427 bp
Protein Name (eCommerce)
N-terminal kinase-like protein
RefSeq ID
NM_020680
RefSeq Synonyms
NM_020680, NM_001048218, BC069233, BC009967,
Research Areas
Cytoskeleton,Golgi Apparatus,Immunology,Kinase/Phosphatase,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
TEIF (telomerase transcriptional element-interacting factor) belongs to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes [taken from NCBI Entrez Gene (GeneID: 57410)].
UniGene ID
Hs.238839
UniProt ID (eCommerce)
Q96KG9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.