human BACE2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-201931
Availability:
3-5 weeks
Name:
AAV-h-BACE2
This is an AAV expressing Human BACE2.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- BACE2
- Gene Name
- beta-site APP-cleaving enzyme 2
- Gene ID
- 25825
- Gene Synonyms
- AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
- ORF Size
- 1557 bp
- RefSeq#
- BC014453
- Gene Description
- Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
- UniGene ID
- Hs.529408
- HGNC ID
- HGNC:934
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