Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PROC

Gene Name

protein C, inactivator of coagulation factors Va and VIIIa

Gene ID

5624

Gene Synonyms

APC; PC; PROC1; THPH3; THPH4

ORF Size

1386 bp

RefSeq#

BC034377

Gene Description

PROC encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

UniGene ID

Hs.224698

HGNC ID

HGNC:9451