Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

LMBR1

Gene Name

limb development membrane protein 1

Gene ID

64327

Gene Synonyms

ACHP; C7orf2; DIF14; LSS; PPD2; THYP; TPT; ZRS

ORF Size

1473 bp

RefSeq#

BC017663

Gene Description

LMBR1 encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression.

UniGene ID

Hs.209989

HGNC ID

HGNC:13243