Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

DCLRE1C

Gene Name

DNA cross-link repair 1C

Gene ID

64421

Gene Synonyms

A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C

ORF Size

1305 bp

RefSeq#

BC022254

Gene Description

DCLRE1C encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).

UniGene ID

Hs.656065

HGNC ID

HGNC:17642