PUMA (DBH3)

Product Category: human Adenovirus Type5 (dE1/E3)

Description:

PUMA (p53 up-regulated modulator of apoptosis) is a BH3-only protein. Each of the ??A?BH3-only??A? group of proteins contains an amphipathic Bcl-2 homology (BH) domain. These proteins act as sensors of discrete apoptotic stimuli, antagonizing or activating the function of multidomain Bcl-2 family proteins by interacting with them. This in turn triggers a cascade of downstream events, such as the collapse of mitochondrial membrane potential, release of the apoptogenic mitochondrial proteins cytochrome c and SMAC, and activation of caspases. PUMA plays a vital role in mediating the apoptotic responses to p53. It can be activated by p53 directly through p53-responsive elements in its promoter region. The PUMA protein interacts with Bcl-XL and promotes mitochondrial translocation and multimerization of Bax.

This adenovirus contain PUMA (DBH3).

Reference: Yu J., et al., Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1931-6.

Titer: 1x10¹⁰ PFU/ml *

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

Cat. No.	Tag	Promoter		Species	Price **
1289	GFP			Human	$445.00

• * titer may vary depends on batch
  
• ** Price for US/Canada customers only, please inquire about international pricing.