PUMA (DBH3)
Product Name: Ad-PUMA (DBH3)
Product Category: human Adenovirus Type5 (dE1/E3)
Description: PUMA (p53 up-regulated modulator of apoptosis) is a BH3-only protein.
Each of the ??A?BH3-only??A? group of proteins contains an amphipathic Bcl-2 homology (BH) domain. These proteins act as sensors of discrete apoptotic stimuli, antagonizing or activating the function of multidomain Bcl-2 family proteins by interacting with them. This in turn triggers a cascade of downstream events, such as the collapse of mitochondrial membrane potential, release of the apoptogenic mitochondrial proteins cytochrome c and SMAC, and activation of caspases.
PUMA plays a vital role in mediating the apoptotic responses to p53. It can be activated by p53 directly through p53-responsive elements in its promoter region. The PUMA protein interacts with Bcl-XL and promotes mitochondrial translocation and multimerization of Bax.
This adenovirus contain PUMA (DBH3).
Reference: Yu J., et al., Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1931-6.
Titer: 1x1010 PFU/ml *
Volume: 200ul
Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol
| Cat. No. |
Tag |
Promoter |
|
Species |
Price ** |
 |
| 1289 |
GFP |
|
|
Human |
$445.00 |
- * titer may vary depends on batch
- ** Price for US/Canada customers only, please inquire about international pricing.
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