human BBC3 Over-expression AAV
This is an AAV expressing Human BBC3.
AAV-201991
AAV-h-BBC3
Ready-to-use AAV expressing Human BBC3 (BCL2 binding component 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FLJ42994; JFY1; PUMA;
Description (Vector)
BBC3 encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Gene ID
27113
Gene Symbol
BBC3
ORF Size (bp)
582 bp
RefSeq ID
NM_014417
RefSeq Synonyms
NM_014417, NM_001127242, NM_001127241, NM_001127240, BC136481,
Species
human
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.