mouse TNPO1 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-281172
Availability:
4-5 weeks
Name:
AAV-m-TNPO1-shRNA
This is an AAV expressing shRNA for silencing of Mouse Tnpo1.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Tnpo1
- Gene Name
- transportin 1
- Gene ID
- 238799
- Gene Synonyms
- AU021749; D13Ertd688e; IPO2; Kpnb2; MIP; MIP1; TRN
- ORF Size
- 2673 bp
- RefSeq#
- NM_178716
- Gene Description
- Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
- UniGene ID
- Mm.173286
Related Products
Product | Cat No. |
---|---|
AAV-h-TNPO1 | AAV-226150 |
AAV-m-TNPO1 | AAV-281172 |
Ad-h-TNPO1 | ADV-226150 |
Ad-m-TNPO1 | ADV-281172 |
AAV-h-TNPO1-shRNA | shAAV-226150 |
Ad-h-TNPO1-shRNA | shADV-226150 |
Ad-m-TNPO1-shRNA | shADV-281172 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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