mouse ITPA shRNA silencing AAV

Cat. No: shAAV-262481

Availability: 4-5 weeks

Name: AAV-m-ITPA-shRNA

This is an AAV expressing shRNA for silencing of Mouse Itpa.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Itpa
Gene Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Gene ID: 16434
Gene Synonyms: 2010016I08Rik; AU020102; Itp
ORF Size: 597 bp
RefSeq#: NM_025922
Gene Description: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
UniGene ID: Mm.21399