mouse GPR44 shRNA silencing AAV

Cat. No: shAAV-260642

Availability: 6-8 weeks

Name: AAV-m-GPR44-shRNA

This is an AAV expressing shRNA for silencing of Mouse Ptgdr2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Ptgdr2
Gene Name: prostaglandin D2 receptor 2
Gene ID: 14764
Gene Synonyms: Crth2; Gpr44; Grp45
ORF Size: 1149 bp
RefSeq#: NM_009962
Gene Description: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UniGene ID: Mm.470721