human GP1BB shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-232193
Availability:
6-8 weeks
Name:
AAV-h-GP1BB-shRNA
This is an AAV expressing shRNA for silencing of Human GP1BB.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- GP1BB
- Gene Name
- glycoprotein Ib platelet beta subunit
- Gene ID
- 2812
- Gene Synonyms
- BDPLT1; BS; CD42C; GPIBB; GPIbbeta
- ORF Size
- 621 bp
- RefSeq#
- NM_000407
- Gene Description
- Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.
- UniGene ID
- Hs.
- HGNC ID
- HGNC:4440
Related Products
Product | Cat No. |
---|---|
AAV-h-GP1BB | AAV-232193 |
AAV-m-GP1BB | AAV-260474 |
Ad-h-GP1BB | ADV-232193 |
Ad-m-GP1BB | ADV-260474 |
AAV-m-GP1BB-shRNA | shAAV-260474 |
Ad-h-GP1BB-shRNA | shADV-232193 |
Ad-m-GP1BB-shRNA | shADV-260474 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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