human D2HGDH shRNA silencing AAV

Name
AAV-h-D2HGDH-shRNA

Cat No
shAAV-206557

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human D2HGDH.

shAAV-206557

AAV-h-D2HGDH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human D2HGDH (D-2-hydroxyglutarate dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

D2HGD

Description (Vector)

D2HGDH encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

Gene ID

728294

Gene Name (Vector)

D-2-hydroxyglutarate dehydrogenase

Gene Symbol

D2HGDH

HGNC ID

HGNC:28358

ORF Size (aa)

1566

ORF Size (bp)

1566 bp

RefSeq ID

NM_152783

RefSeq Synonyms

NM_152783, NM_001287249, BC071598, BC036604, BC031817,

Species

human

UniGene ID

Hs.535639

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.