human RASGRF1 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-232049
Availability:
6-8 weeks
Name:
AAV-h-RASGRF1-shRNA
This is an AAV expressing shRNA for silencing of Human RASGRF1.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- RASGRF1
- Gene Name
- Ras protein specific guanine nucleotide releasing factor 1
- Gene ID
- 5923
- Gene Synonyms
- CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55; PP13187; ras-GRF1
- ORF Size
- 3546 bp
- RefSeq#
- NM_002891
- Gene Description
- RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
- UniGene ID
- Hs.459035
- HGNC ID
- HGNC:9875
Related Products
Product | Cat No. |
---|---|
Ad-h-RASGRF1 | ADV-232049 |
Ad-m-RASGRF1 | ADV-270170 |
AAV-m-RASGRF1-shRNA | shAAV-270170 |
Ad-h-RASGRF1-shRNA | shADV-232049 |
Ad-m-RASGRF1-shRNA | shADV-270170 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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