human SLC12A3 shRNA silencing AAV

Cat. No: shAAV-223087

Availability: 6-8 weeks

Name: AAV-h-SLC12A3-shRNA

This is an AAV expressing shRNA for silencing of Human SLC12A3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SLC12A3
Gene Name: solute carrier family 12 member 3
Gene ID: 6559
Gene Synonyms: NCC; NCCT; TSC
ORF Size: 3090 bp
RefSeq#: NM_000339
Gene Description: SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.669115
HGNC ID: HGNC:10912