human SLC12A3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SLC12A3.
shADV-223087
Ad-h-SLC12A3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SLC12A3 (solute carrier family 12 member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NCC; NCCT; TSC
Description (Vector)
SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6559
Gene Name (Vector)
solute carrier family 12 member 3
Gene Symbol
SLC12A3
HGNC ID
HGNC:10912
ORF Size (aa)
3090
ORF Size (bp)
3090 bp
RefSeq ID
NM_000339
RefSeq Synonyms
NM_001126108, NM_001126107, NM_000339, BC111850,
Species
human
UniGene ID
Hs.669115
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.