human RNF111 shRNA silencing AAV

Cat. No: shAAV-221327

Availability: 6-8 weeks

Name: AAV-h-RNF111-shRNA

This is an AAV expressing shRNA for silencing of Human RNF111.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RNF111
Gene Name: ring finger protein 111
Gene ID: 54778
Gene Synonyms: ARK
ORF Size: 2958 bp
RefSeq#: NM_017610
Gene Description: RNF111 is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
UniGene ID: Hs.404423
HGNC ID: HGNC:17384