human PTPN18 shRNA silencing AAV

Cat. No: shAAV-220313

Availability: 6-8 weeks

Name: AAV-h-PTPN18-shRNA

This is an AAV expressing shRNA for silencing of Human PTPN18.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PTPN18
Gene Name: protein tyrosine phosphatase, non-receptor type 18
Gene ID: 26469
Gene Synonyms: BDP1; PTP-HSCF
ORF Size: 1056 bp
RefSeq#: NM_014369
Gene Description: PTPN18 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.591549
HGNC ID: HGNC:9649