human POLR2E shRNA silencing AAV

Cat. No: shAAV-219394

Availability: 4-5 weeks

Name: AAV-h-POLR2E-shRNA

This is an AAV expressing shRNA for silencing of Human POLR2E.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: POLR2E
Gene Name: RNA polymerase II subunit E
Gene ID: 5434
Gene Synonyms: hRPB25; hsRPB5; RPABC1; RPB5; XAP4
ORF Size: 633 bp
RefSeq#: NM_002695
Gene Description: POLR2E encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.
UniGene ID: Hs.24301
HGNC ID: HGNC:9192