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mouse POLR2E shRNA silencing Adenovirus

Name 
Ad-m-POLR2E-shRNA
Cat No 
shADV-269038
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Polr2e.

shADV-269038
Ad-m-POLR2E-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Polr2e (polymerase (RNA) II (DNA directed) polypeptide E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2410021N14Rik; 25kDa; AW208866; RPB5; XAP4
Description (Vector)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
Gene ID
66420
Gene Name (Vector)
polymerase (RNA) II (DNA directed) polypeptide E
Gene Symbol
Polr2e
ORF Size (aa)
489
RefSeq ID
NM_025554
RefSeq Synonyms
NM_025554, BC045521, BC026842,
Species
mouse
UniGene ID
Mm.18579

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.