human PDE1B shRNA silencing AAV

Cat. No: shAAV-218462

Availability: 6-8 weeks

Name: AAV-h-PDE1B-shRNA

This is an AAV expressing shRNA for silencing of Human PDE1B.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDE1B
Gene Name: phosphodiesterase 1B
Gene ID: 5153
Gene Synonyms: HEL-S-79p; PDE1B1; PDES1B
ORF Size: 1611 bp
RefSeq#: NM_000924
Gene Description: PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniGene ID: Hs.530871
HGNC ID: HGNC:8775