human KCNN4 shRNA silencing AAV

Cat. No: shAAV-212769

Availability: 4-5 weeks

Name: AAV-h-KCNN4-shRNA

This is an AAV expressing shRNA for silencing of Human KCNN4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: KCNN4
Gene Name: potassium calcium-activated channel subfamily N member 4
Gene ID: 3783
Gene Synonyms: DHS2; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; SK4
ORF Size: 1284 bp
RefSeq#: NM_002250
Gene Description: KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
UniGene ID: Hs.10082
HGNC ID: HGNC:6293