human ITPA shRNA silencing AAV

Cat. No: shAAV-212542

Availability: 4-5 weeks

Name: AAV-h-ITPA-shRNA

This is an AAV expressing shRNA for silencing of Human ITPA.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ITPA
Gene Name: inosine triphosphatase
Gene ID: 3704
Gene Synonyms: C20orf37; dJ794I6.3; HLC14-06-P; ITPase; My049; NTPase
ORF Size: 585 bp
RefSeq#: NM_033453
Gene Description: ITPA encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.
UniGene ID: Hs.415299
HGNC ID: HGNC:6176