human IRF4 shRNA silencing AAV

Cat. No: shAAV-212408

Availability: 6-8 weeks

Name: AAV-h-IRF4-shRNA

This is an AAV expressing shRNA for silencing of Human IRF4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IRF4
Gene Name: interferon regulatory factor 4
Gene ID: 3662
Gene Synonyms: LSIRF; MUM1; NF-EM5; SHEP8
ORF Size: 1356 bp
RefSeq#: NM_002460
Gene Description: IRF4 belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
UniGene ID: Hs.401013
HGNC ID: HGNC:6119