human GRIK3 shRNA silencing AAV

Cat. No: shAAV-210516

Availability: 6-8 weeks

Name: AAV-h-GRIK3-shRNA

This is an AAV expressing shRNA for silencing of Human GRIK3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GRIK3
Gene Name: glutamate ionotropic receptor kainate type subunit 3
Gene ID: 2899
Gene Synonyms: EAA5; GLR7; GluK3; GLUR7; GluR7a
ORF Size: 2760 bp
RefSeq#: NM_000831
Gene Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
UniGene ID: Hs.128848
HGNC ID: HGNC:4581