human ERCC5 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-208062
Availability:
6-8 weeks
Name:
AAV-h-ERCC5-shRNA
This is an AAV expressing shRNA for silencing of Human ERCC5.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ERCC5
- Gene Name
- ERCC excision repair 5, endonuclease
- Gene ID
- 2073
- Gene Synonyms
- COFS3; ERCC5-201; ERCM2; UVDR; XPG; XPGC
- ORF Size
- 3561 bp
- RefSeq#
- NM_000123
- Gene Description
- ERCC5 encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
- UniGene ID
- Hs.258429
- HGNC ID
- HGNC:3437
Related Products
Product | Cat No. |
---|---|
Ad-h-ERCC5 | ADV-208062 |
Ad-m-ERCC5 | ADV-258636 |
AAV-m-ERCC5-shRNA | shAAV-258636 |
Ad-h-ERCC5-shRNA | shADV-208062 |
Ad-m-ERCC5-shRNA | shADV-258636 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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