human CYP46A1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-206508
Availability:
3-5 weeks
Name:
AAV-h-CYP46A1
This is an AAV expressing Human CYP46A1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CYP46A1
- Gene Name
- cytochrome P450 family 46 subfamily A member 1
- Gene ID
- 10858
- Gene Synonyms
- CP46; CYP46
- ORF Size
- 1503 bp
- RefSeq#
- BC022539
- Gene Description
- CYP46A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
- UniGene ID
- Hs.25121
- HGNC ID
- HGNC:2641
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