human YWHAE Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-228002
Availability:
3-5 weeks
Name:
AAV-h-YWHAE
This is an AAV expressing Human YWHAE.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- YWHAE
- Gene Name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
- Gene ID
- 7531
- Gene Synonyms
- 14-3-3E; HEL2; KCIP-1; MDCR; MDS
- ORF Size
- 768 bp
- RefSeq#
- BC000179
- Gene Description
- YWHAE product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
- UniGene ID
- Hs.513851
- HGNC ID
- HGNC:12851
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