human TNFSF4 Over-expression AAV

Name 
AAV-h-TNFSF4
Cat No 
AAV-226112
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TNFSF4.

AAV-226112
AAV-h-TNFSF4

Ready-to-use AAV expressing Human TNFSF4 (tumor necrosis factor superfamily member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD252; CD134 ligand; CD134L; CD252; glycoprotein Gp34; GP34; OX40 antigen ligand; OX40 ligand; OX40L; OX-40L; OX4OL; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); TNLG2B; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor ligand 2B; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; TXGP1
Description (eCommerce)
OX40L/TNFSF4 is a cytokine of the tumor necrosis factor (TNF) ligand family. OX40L/TNFSF4 functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. [taken from NCBI Entrez Gene (Gene ID: 7292)].
Description (Vector)
TNFSF4 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
Gene ID
7292
Gene Name (eCommerce)
TNF superfamily member 4
Gene Name (Vector)
tumor necrosis factor superfamily member 4
Gene Symbol
TNFSF4
HGNC ID
HGNC:11934
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
402
Protein Name (eCommerce)
Tumor necrosis factor ligand superfamily member 4
RefSeq ID
NM_003326
RefSeq Synonyms
NM_003326, NM_001297562, BC041663,
Research Areas
Cancer,Host-Virus Interactions,Immunology,Response to Virus,Signal Transduction,TSLP Signaling
Research Areas (Faceted)
cancer,signal_transduction,infectious_disease,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
OX40L/TNFSF4 is a cytokine of the tumor necrosis factor (TNF) ligand family. OX40L/TNFSF4 functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. [taken from NCBI Entrez Gene (Gene ID: 7292)].
UniGene ID
Hs.181097
UniProt ID (eCommerce)
P23510

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.