human TXNRD1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-226929
Availability:
Immediate
Name:
AAV-h-TXNRD1
This is an AAV expressing Human TXNRD1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- TXNRD1
- Gene Name
- thioredoxin reductase 1
- Gene ID
- 7296
- Gene Synonyms
- GRIM-12; TR; TR1; TRXR1; TXNR
- ORF Size
- 1500 bp
- RefSeq#
- BC018122
- Gene Description
- TXNRD1 encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
- UniGene ID
- Hs.708065
- HGNC ID
- HGNC:12437
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