human DYNLL1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-207469
Availability:
3-5 weeks
Name:
AAV-h-DYNLL1
This is an AAV expressing Human DYNLL1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- DYNLL1
- Gene Name
- dynein light chain LC8-type 1
- Gene ID
- 8655
- Gene Synonyms
- DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8; LC8a; PIN
- ORF Size
- 270 bp
- RefSeq#
- BC100289
- Gene Description
- Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.
- UniGene ID
- Hs.5120
- HGNC ID
- HGNC:15476
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