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human CTLA4 Over-expression AAV

Name 
AAV-h-CTLA4
Cat No 
AAV-206235
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CTLA4.

AAV-206235
AAV-h-CTLA4

Ready-to-use AAV expressing Human CTLA4 (cytotoxic T-lymphocyte associated protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ALPS5;CD;CD antigen CD152;CD152;CD152 isoform;celiac disease 3;CELIAC3;CTLA-4;cytotoxic T lymphocyte associated antigen 4 short spliced form;cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;cytotoxic T-lymphocyte-associated serine esterase-4;GRD4;GSE;IDDM12;insulin-dependent diabetes mellitus 12;ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Description (eCommerce)
CTLA4 is a member of the immunoglobulin superfamily and is an inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16410].
Description (Vector)
CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Gene ID
1493
Gene Name (eCommerce)
cytotoxic T-lymphocyte associated protein 4
Gene Name (Vector)
cytotoxic T-lymphocyte associated protein 4
Gene Symbol
CTLA4
HGNC ID
HGNC:2505
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
672
ORF Size (bp)
672 bp
Protein Name (eCommerce)
Cytotoxic T-lymphocyte protein 4
RefSeq ID
NM_005214
RefSeq Synonyms
NM_005214, NM_001037631, BC074893, BC074842, BC070162, BC069566,
Research Areas
Apoptosis,B Cell Receptor Signaling,DNA Damage/Repair,Golgi Apparatus,Immunology,Signal Transduction,T Cell Receptor Signaling
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,immunology,signal_transduction
Species
human
Target Sentence
CTLA4 is a member of the immunoglobulin superfamily and is an inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16410].
UniGene ID
Hs.247824
UniProt ID (eCommerce)
P16410

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.