human DUX4 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-207450
Availability:
3-5 weeks
Name:
AAV-h-DUX4
This is an AAV expressing Human DUX4.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- DUX4
- Gene Name
- double homeobox 4
- Gene ID
- 22947
- Gene Synonyms
- DUX10;
- ORF Size
- 1275 bp
- RefSeq#
- BC160122
- Gene Description
- DUX4 is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD).
- UniGene ID
- Hs.553518
Related Products
Product | Cat No. |
---|---|
Ad-h-DUX4 | ADV-207450 |
AAV-h-DUX4-shRNA | shAAV-207450 |
Ad-h-DUX4-shRNA | shADV-207450 |
Control Products
Vector Biolabs
293 Great Valley Parkway
Malvern, PA 19355
Email: info@vectorbiolabs.com
Phone: +1 484-325-5100
Toll-free (US Only): 877-BIO-LABS
Fax: +1 215-525-1112
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