VEGF/VPF receptor Adenovirus

Name 
Ad-VEGF-R1
Cat No 
1437
Availability
Immediate
Categories
Adenovirus, Over-Expression

Three cell membrane receptor tyrosine kinases Flt-1 (also designated VEGF-R1), Flk-1 (also designated VEGF-R2 or KDR) and Flt-4 (putatively involved in the growth of endothelial cells) are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domains. Two members of this receptor class, Flt-1 and Flk-1, represent high affinity receptors for vascular endothelial growth factor (VEGF). On the basis of structural similarity to Flt-1 and Flk-1, Flt-4 may represent a third receptor for either VEGF or a VEGF-related ligand. Flt-3/ Flk-2 and its human homolog, STK-1, are expressed at high levels in hematopoietic cells and also in neural, gonadal, hepatic and placental tissues.

This is an adenovirus expressing human sFlt1.

1437
Ad-VEGF-R1

Ready-to-use VEGF/VPF receptor Adenovirus. Ad-VEGF-R1, VEGF/VPF receptor, sFLT,FLT1,VEGFR1, VEGFR, FLT-1, VEGF-R1 cat#1437

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
FLT; FLT-1; VEGFR-1; VEGFR1
Description (Vector)
FLT1 encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Gene ID
2321
Gene Name (Vector)
fms related tyrosine kinase 1
Gene Symbol
FLT1
HGNC ID
HGNC:3763
ORF Size (aa)
2064
ORF Size (bp)
2064 bp
RefSeq ID
NM_002019
RefSeq Synonyms
NM_002019, NM_001160031, NM_001160030, NM_001159920, BC039007,
Species
human
UniGene ID
Hs.654360

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.