rat JMJD5 shRNA silencing AAV

Cat. No: shAAV-294378

Availability: 6-8 weeks

Name: AAV-r-JMJD5-shRNA

This is an AAV expressing shRNA for silencing of Rat Kdm8.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Kdm8
Gene Name: lysine demethylase 8
Gene ID: 308976
Gene Synonyms: Jmjd5; RGD1304823
ORF Size: 1245 bp
RefSeq#: NM_001037196
Gene Description: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.