human TGFBI shRNA silencing AAV

Cat. No: shAAV-225388

Availability: 4-5 weeks

Name: AAV-h-TGFBI-shRNA

This is an AAV expressing shRNA for silencing of Human TGFBI.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TGFBI
Gene Name: transforming growth factor beta induced
Gene ID: 7045
Gene Synonyms: BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; LCD1
ORF Size: 2052 bp
RefSeq#: NM_000358
Gene Description: TGFBI encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
UniGene ID: Hs.369397
HGNC ID: HGNC:11771