human NAGS shRNA silencing AAV

Cat. No: shAAV-216293

Availability: 6-8 weeks

Name: AAV-h-NAGS-shRNA

This is an AAV expressing shRNA for silencing of Human NAGS.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NAGS
Gene Name: N-acetylglutamate synthase
Gene ID: 162417
Gene Synonyms: AGAS; ARGA
ORF Size: 1107 bp
RefSeq#: NM_153006
Gene Description: The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.
UniGene ID: Hs.8876
HGNC ID: HGNC:17996